Sildenafil can induce the onset of a cluster headache bout
May 21, 2014· Central inhibition of PDE-11 can cause cerebral vasodilatation and migraine attacks. 2 Four cases of cluster headaches triggered by sildenafil were reported between 1999 and 2006. 6 – 8 Common triggers of cluster headache include exogenous histamine, vasodilators (e.g., alcohol, nitroglycerin), and cigarette smoking. 9 In our case, the ...