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The role of the vgf gene and VGF-derived peptides in ...

The vgf gene and VGF-derived peptides. The number of genes involved in the regulation of nutrition and metabolism is enormous [].Among these genes, vgf is gaining increasing interest following two observations: (1) VGF-/- mice have a lean and hypermetabolic phenotype [33, 34], (2) the first VGF-derived peptide involved in energy homeostasis has been identified [].

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VGF function in depression and antidepressant efficacy

VGF expression is regulated by depression in a region-specific manner. (A) Timeline of 10-day chronic social defeat (CSDS) experiment and coronal schematics of mouse brain highlighting dorsal hippocampus (dHc) and nucleus accumbens (NAc) collected.Brain atlas adapted from Allen Brain Institute 24.Social interaction test and tissue collection were performed 24h and 48h after the last …

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VGF - Wikipedia

VGF or VGF nerve growth factor inducible is a secreted protein and neuropeptide precursor that may play a role in regulating energy homeostasis, metabolism and synaptic plasticity. The protein was first discovered in 1985 by Levi et al. in an experiment with PC12 cells and its name is non-acronymic.VGF gene encodes a precursor which is divided by proteolysis to polypeptides of different mass ...

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VGF Gene - GeneCards | VGF Protein | VGF Antibody

Cloning, structural organization analysis, and chromosomal assignment of the human gene for the neurosecretory protein VGF. (PMID: 9344675) Canu N … Levi A (Genomics 1997) 2 3 4 23 54; The expression of VGF is reduced in leukocytes of depressed patients and it is restored by effective antidepressant treatment. (PMID: 20164831) Cattaneo A …

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G Marktredwitz - Wunsiedel VGF-Linie Ã 10

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Index of /vgf

Index of /vgf. Name Last modified Size; Parent Directory - 20120109: 09-Jan-2012 12:09 : 19K

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VGF function in depression and antidepressant efficacy ...

Nov 21, 2017· VGF is therefore a critical modulator of depression-like behaviors in dHc and NAc. In hippocampus, the antidepressant response to ketamine is associated with rapid VGF …

Chromodomain Y-like Protein–Mediated Histone Crotonylation ...

The PFC controls higher-level “executive” functions and is intimately involved in MDD 28, 29, 30.C57BL/6 adult male mice were subjected to CSDS, an ethologically validated model of depression , and experimental mice were classified as susceptible or resilient based on their social interaction time ().Forty-eight hours after the last social defeat, histones were acid-extracted from mPFC ...

VGF: a biomarker and potential target for the treatment of ...

VGF has a tissue-specific pattern of expression and is robustly regulated and synthesised in immune cells, neuronal cells, and neuroendocrine cells of both the central and peripheral nervous system. 14,15,18,54,79,86,94 In the peripheral nervous system, VGF is highly expressed in both neurons of the sympathetic ganglia and dorsal root ganglia ...

VGF-derived peptide TLQP-21 modulates microglial function ...

TLQP-21 increases BV2 cell migration and phagocytotic activity. TLQP-21 is a bioactive C-terminal VGF-derived neuropeptide and the R21A mutation of its C-terminal amino acid eliminates its activation of the complement component 3a (C3a) receptor-1 (C3aR1) [] (Fig. 1a).As C3aR1 is a target of TLQP-21 [5, 24, 25], we compared TLQP-21 with the C-terminal synthetic analogue of C3a (C3aSA) which is ...

VGF, a New Player in Antidepressant Action?

Mood disorders are prevalent forms of mental illness. Major depression is one of the most common mental illnesses that affects up to 20% of the general U.S. population (1–3).Major depression is characterized by anhedonia, which is the inability to experience pleasure from normally pleasurable events, alterations in cognition, intense feelings of sadness and despair, agitation, and self ...

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Association of Promoter Methylation of VGF and PGP9.5 with ...

Experimental Design. PH of PGP9.5, HIC1, AIM1, APC, PAK3, MGMT, KIF1A, CCNA1, ESR1, SSBP2, GSTP1, FKBP4 and VGF were assessed by quantitative methylation specific PCR (QMSP) in a training set. We selected two genes (VGF and PGP9.5) for further QMSP analysis in a larger independent validation (IV) set with available clinical data.Biologic relevance of VGF gene was also evaluated.

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